R. Douglas Wright Biomedical Career Development Award - (Regulation of Airway Defensive Reflexes)

Evidence for multiple sensory circuits in the brain arising from the respiratory system: an anterograde viral tract tracing study in rodents

AE McGovern, N Davis-Poynter, SK Yang, DG Simmons, MJ Farrell, SB Mazzone

2014-08-27

Complex sensations accompany the activation of sensory neurons within the respiratory system, yet little is known about the organi..

Autonomic neural control of the airways

SB Mazzone, BJ Canning

2013-01-01

The airways and lungs are innervated by both sympathetic and parasympathetic nerves. Cholinergic parasympathetic innervation is we..

Anterograde neuronal circuit tracing using a genetically modified herpes simplex virus expressing EGFP

AE McGovern, N Davis-Poynter, J Rakoczy, S Phipps, DG Simmons, SB Mazzone

2012-07-30

Insights into the anatomical organization of complex neural circuits provide important information about function, and thus tools ..

Neural correlates coding stimulus level and perception of capsaicin-evoked urge-to-cough in humans

MJ Farrell, LJ Cole, D Chiapoco, GF Egan, SB Mazzone

2012-07-16

The perception of airways irritation is represented in a distributed brain network. However, the functional roles of sub-regions o..

Transneuronal tracing of airways-related sensory circuitry using herpes simplex virus 1, strain H129

AE McGovern, N Davis-Poynter, MJ Farrell, SB Mazzone

2012-04-05

Sensory input from the airways to suprapontine brain regions contributes to respiratory sensations and the regulation of respirato..

The effect of placebo conditioning on capsaicin-evoked urge to cough

J Leech, SB Mazzone, MJ Farrell

2012-01-01

Background: The urge to cough is a clinical symptom of respiratory disease that precedes the motor act of coughing. Although previ..

Central nervous system control of cough: Pharmacological implications

SB Mazzone, AE McGovern, LJ Cole, MJ Farrell

2011-06-01

For many years the idea of a cough center in the brain dominated discussions in the field without any substantial progress in defi..

Investigation of the neural control of cough and cough suppression in humans using functional brain imaging

SB Mazzone, LJ Cole, A Ando, GF Egan, MJ Farrell

2011-02-23

Excessive coughing is one of the mostcommonreasons for seeking medical advice, yet the available therapies for treating cough diso..

Characterization of the vagal motor neurons projecting to the Guinea pig airways and esophagus

Alice E McGovern, Stuart B Mazzone

2010-12-17

Distinct parasympathetic postganglionic neurons mediate contractions and relaxations of the guinea pig airways. We set out to char..

Sympathetic nerve-dependent regulation of mucosal vascular tone modifies airway smooth muscle reactivity

SB Mazzone, LHK Lim, EM Wagner, N Mori, BJ Canning

2010-11-01

The airways contain a dense subepithelial microvascular plexus that is involved in the supply and clearance of substances to and f..

Human brain activation associated with cough and cough suppression

Stuart Mazzone, Leonie Cole, Ayaka Ando, Michael Farrell

2010-04-01

<jats:sec> <jats:label/> <jats:p>Supramedullary brain regions may contribute to control of..

Innervation of tracheal parasympathetic ganglia by esophageal cholinergic neurons: Evidence from anatomic and functional studies in guinea pigs

SB Mazzone, AE McGovern

2010-03-01

In the present study, we describe a subset of nerve fibers, characterized by their immunoreactivity for the calcium-binding protei..

Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough

SB Mazzone, SM Reynolds, N Mori, M Kollarik, DG Farmer, AC Myers, BJ Canning

2009-10-28

We have identified a distinct subtype of airway vagal afferent nerve that plays an essential role in regulating the cough reflex. ..

Mapping supramedullary pathways involved in cough using functional brain imaging: Comparison with pain

SB Mazzone, AE McGovern, K Koo, MJ Farrell

2009-04-01

Several indications suggest that supramedullary brain regions receive sensory information from the airways and provide motor contr..

Immunohistochemical characterization of nodose cough receptor neurons projecting to the trachea of guinea pigs

Stuart B Mazzone, Alice E McGovern

2008-10-19

BACKGROUND: Cough in guinea pigs is mediated in part by capsaicin-insensitive low threshold mechanoreceptors (cough receptors). Fu..

Sensory neural targets for the treatment of cough

SB Mazzone, AE McGovern

2007-10-01

1. Cough is a primary defensive reflex that protects the airways from potentially harmful stimuli. 2. During many respiratory dise..